![]() In males, low testosterone levels may cause depression, along with irritability and fatigue. People may have a persistent depressive disorder if they have a low mood most days for 2 years. People may have depression if they have depressive symptoms for more than 2 weeks. injury, surgery, or cancer treatment that affects reproductive organs.It is also normal for people to experience sadness and lower mood at times.ĭepression may be hormonal if people have severe mood changes that link to a change in hormones, which may occur with: How do I know whether I’m experiencing depression or hormonal changes? Low testosterone levels may also cause depression. Increased levels of progesterone, such as through taking a progesterone-only contraceptive, may also increase the risk of depression in some people. What hormones cause depression?Ī drop in estrogen and progesterone may trigger depressive episodes. This section answers some frequently asked questions about hormonal imbalances and depression. The link may be due to levels of thyroid hormones and the regulation and function of the thyroid gland, as well as sex assigned at birth. Researchers concluded there may be a moderate link between overt hypothyroidism, rather than subclinical hypothyroidism, and clinical depression in females. There is conflicting evidence on whether thyroid disorders are linked to depression, but thyroid disorders may share similar symptoms to depression.Ī 2021 meta-analysis found that the link between depression and thyroid disorders may be less than previous research has suggested. ![]() hypopituitarism, a pituitary gland disorder.removal of the ovaries or ovarian failure.Symptoms of androgen deficiency in females may include:Ĭauses of androgen deficiency in females may include: This makes low testosterone harder to diagnose in females. certain medications, including some antidepressants and narcoticsįemales produce lower levels of androgens, such as testosterone, than males.injury to testicles or removal of testicles.Possible causes of low testosterone in males can include: Other symptoms of low testosterone include: In males, low testosterone levels may cause depression. Changes in hormone levels and allopregnanolone during pregnancy may affect how GABA receptors function. GABA receptors are a type of receptor in the brain that plays a role in many mental health conditions, such as depression. In some people, levels do not rise, which can lead to depression. In many cases, allopregnanolone levels will rise after a few days of giving birth. Research suggests this swift change in allopregnanolone plays a major role in postpartum depression. After childbirth, allopregnanolone levels rapidly fall. Postpartum depressionĪllopregnanolone is a neurosteroid, a type of steroid that the brain produces, that naturally occurs from the breakdown of progesterone.ĭuring pregnancy, levels of allopregnanolone steadily increase up to the third trimester. People with a history of depression may also be more likely to experience depression during perimenopause. Difficulty sleeping can make it 10 times more likely for a person to experience depression. Other symptoms of perimenopause, such as hot flashes, may also cause sleep problems. Perimenopause, the transition into menopause, can cause mood changes and may increase feelings of sadness and anxiety.ĭuring perimenopause, estrogen and progesterone levels fall, which can trigger mood changes and may cause episodes of depression. ![]() This may be due to the effect progesterone has on certain neurotransmitters, which can result in lower levels of serotonin. Hormonal contraceptivesĪccording to a 2022 research article, hormonal contraception may cause or contribute to depression in some people due to the quantity and type of progesterone the contraception contains.Įstrogen and progesterone are hormones that affect brain function, the nervous system, and neurotransmitters such as serotonin and dopamine.Įstrogen may have protective effects against mood disorders, but progesterone may worsen mood. PMDD may occur from an increased sensitivity to hormonal changes during the menstrual cycle, which includes changes in serotonin levels. Symptoms may occur 1 or 2 weeks before the beginning of a period, when hormone levels start to drop. ![]()
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